Das SPOX NFL All-Pro-Team 2021 im Überblick:
All-Pro Team 2021 First und Second Team - die Offense:
| Position | First Team | Second Team |
| Quarterback | Aaron Rodgers, Green Bay Packers | Tom Brady, Tampa Bay Buccaneers |
| Running Back | Jonathan Taylor, Indianapolis Colts | Austin Ekeler, Los Angeles Chargers |
| Tight End | George Kittle, San Francisco 49ers | Mark Andrews, Baltimore Ravens |
| Wide Receiver | Davante Adams, Green Bay Packers | Ja'Marr Chase, Cincinnati Bengals |
| Slot-Receiver | Cooper Kupp, Los Angeles Rams | Hunter Renfrow, Las Vegas Raiders |
| Wide Receiver | Justin Jefferson, Minnesota Vikings | Deebo Samuel, San Francisco 49ers |
| Left Tackle | Trent Williams, San Francisco 49ers | Rashawn Slater, Los Angeles Chargers |
| Left Guard | Joel Bitonio, Cleveland Browns | Joe Thuney, Kansas City Chiefs |
| Center | Creed Humphrey, Kansas City Chiefs | Jason Kelce, Philadelphia Eagles |
| Right Guard | Zack Martin, Dallas Cowboys | Wyatt Teller, Cleveland Browns |
| Right Tackle | Lane Johnson, Philadelphia Eagles | Tristan Wirfs, Tampa Bay Buccaneers |
All-Pro Team 2021 First und Second Team - die Defense:
| Position | First Team | Second Team |
| Edge-Rusher | T.J. Watt, Pittsburgh Steelers | Nick Bosa, San Francisco 49ers |
| Edge-Rusher | Myles Garrett, Cleveland Browns | Maxx Crosby, Las Vegas Raiders |
| Interior Defensive Line | Aaron Donald, Los Angeles Rams | DeForest Buckner, Indianapolis Colts |
| Interior Defensive Line | Chris Jones, Kansas City Chiefs | Cam Heyward, Pittsburgh Steelers |
| Linebacker | De'Vondre Campbell, Green Bay Packers | Roquan Smith, Chicago Bears |
| Linebacker | Micah Parsons, Dallas Cowboys | Demario Davis, New Orleans Saints |
| Linebacker | Darius Leonard, Indianapolis Colts | Jeremiah Owusu-Koramoah, Cleveland Browns |
| Cornerback | J.C. Jackson, New England Patriots | Marshon Lattimore, New Orleans Saints |
| Cornerback | A.J. Terrell, Atlanta Falcons | Casey Hayward, Las Vegas Raiders |
| Slot-Cornerback | Jalen Ramsey, Los Angeles Rams | Kenny Moore, Indianapolis Colts |
| Safety | Kevin Byard, Tennessee Titans | Jevon Holland, Miami Dolphins |
| Safety | Budda Baker, Arizona Cardinals | Marcus Williams, New Orleans Saints |
